Mark T. Clunes, PhD

Department of Physiology/Neuroscience
Senior Associate Dean
Dean of Basic Sciences Office
Phone: (473) 444-4175 ext. 3607
Fax: (473) 444-4673

Dr. Clunes received a BSc (Hons) in Biology from the University of Stirling, Scotland, UK, 1995 and a PhD in 1998 from the University of Dundee, Scotland, UK.

Prior to accepting a position as Associate Professor with St. George’s University in Sept. 2008, in the Department of Physiology/Neuroscience, Dr. Clunes worked as a Research Associate with the Cystic Fibrosis Center at the University of North Carolina at Chapel Hill. His work there included the development of a new lung model for drug development – and the registration of that model as an invention with UNC Office of technology Development.

Throughout Dr. Clunes career in science, he has been involved in the elucidation of the mechanisms regulating ion transport in mammalian epithelial cells. The majority of Dr. Clunes work has been based on cellular transduction and the control of fluid/ion secretion and reabsorption, processes vital in osmoregulation and in the normal functioning of many organ systems, e.g. mucociliary clearance and respiration in lungs, chloride cell osmoregulation in fish, motility in gut and thermoregulatory control by sweat glands. To date Dr. Clunes work has involved gaining general insight into the normal physiology of animal epithelia (especially human), and in understanding pathological conditions affecting epithelial function, esp. cystic fibrosis, inflammatory bowel disease and anhydrosis/hyperhidrosis.

Research methodologies Dr. Clunes is competent in include cellular imaging and spectrofluorescence (e.g. Ca2+ and pH measurement), immunohistochemistry, electrophysiology (Patch Clamp and Ussing chamber), molecular techniques, e.g. RT-PCR, Western and Northern blotting, primary and immortalised cell culture, mouse colony management – transgenic generation, and small animal surgery.

Awards received by Dr. Clunes include Geroge John Livanos Prize Studentship while in attendance at the University of Dundee. Patents awarded include Principle Discloser on NCI-H441 (CFTR, R117H, G551D, F508) model as registered with UNC Office of Technology Development (May 2008)